Anemone x hybrid are quite adaptable to shade and even dry conditions, though well-watered plants will bloom best. Space perennial Japanese Anemone plugs about 12 to 18 inches apart to allow for several years' growth. These plants prefer moist but well-drained and fertile soils - do not allow them to dry out, and avoid planting in soils that stay wet. As the plant grows, scout regularly for flea beetles, slugs, and caterpillars that will occasionally chew on the foliage. Japanese Anemones can be susceptible to Synchytrium leaf gall, downy mildrew, Septoria leaf spot, powdery mildew, and some viruses.